Based on the actual demand of fuel tanks for carrier transportation, an anti-fuel diffusion coatings with excellent adhesion was prepared by using polyurethane modified epoxy resin as component A, and polyetheramine compound polyamide as curing agent. The effect of addition of hydroxyl epoxy resin, the selection of curing agent, the mixing ratio of high boiling point solvents and low boiling point solvents and the combination of auxiliaries on the coatings’ properties were systematically investigated. The prepared antifuel diffusion coatings has high elongation at break and excellent tensile strength, it also protect fuel tanks from the harsh corrosive environment.